Enews179 環境荷爾蒙與健康之效應
出自KMU e-News
高雄醫學大學e快報 第179期 環境醫學頂尖研究中心
環境荷爾蒙與健康之效應
環境醫學頂尖研究中心 葛應欽主任
本中心執行環境荷爾蒙相關研究已3年多，目前環境荷爾蒙相關已發表論文及投稿中論文近十篇，且中心之儀器、技術、空間都已建置完成，並於99年與美國國家毒理學研究中心簽訂合作協議書，今年4月15-16日在本校舉辦「2011年食品藥物安全評估國際研討會」；在此基礎下，本中心於6月舉行環境荷爾蒙整合會議，公開徵求研究計畫，並開始規劃及申請IRB等行政工作，預計今年8月開始執行環境荷爾蒙相關研究，以phalate為優先，NP及其他環境荷爾蒙也列入研究重點。
環境荷爾蒙分子機轉及相關基因如下表：
| Reference | ‧Gene Symbols |
| ‧Chih-Hsing Hung, San-Nan Yang, Po-Lin Kuo, Yu-Te Chu, Hui-Wen Chang, Wan-Ju Wei, Shau-Ku Huang, Yuh-Jyh Jong. Modulation of cytokine expression in human myeloid dendritic cells by environmental endocrine disrupting c hemicals involves epigenetic regulation. Environ Health Perspect 2010;118:67-72 | ‧ＴＮＦ-α
‧ＩＬ-10 |
| Huang,P.C.;Tsai,E.M.;Li,W.F.et al. Association between phthalate exposure and glutatione S-transferase MI polymorphism in adenomyosis, leiomyoma and endometriosis. Human Reproduction. 2010,25,986-994. | Glutatione |
| Kuo,P.L.;Hsu,Y.L.; Huang M.S.;Tasi,M.J.;Ko,Y.C..Ginger Suppresses Phthalate Ester-Induced Airway Remodeling.J. Agric. Food Chem. 2011,59,3429-3438. | CYP1B1
IL-8 |
| Singh,S.; Li S.S.L.. Phthalates;Toxicogenomics and inferred human diseases.Genomics. 2011,97,148-157. | CYP1B1
AhR PPARγ |
| Hung-Sheng Chen, Po-Hui Chiang, Yu-Chih Wang, Mi-Chun Kao, Tsung-Hua Shieh, Cheng-Fang Tsai, Eing-Mei Tsai*. Phthalate induces cell necrosis by AhR mediation of CYP1B1 expression in human granulosa cells. Reproductive Toxicology (Revised 2011) | CYP1B1
AhR |
| Po-Lin Kuo,Ying-Chin Ko,et al. Nonylphenol induces bronchial epithelium apoptosis via Fas-mediated pathway and stimulates bronchial epithelium to secrete IL-6 and IL-8, causing bronchial smooth muscle proliferation and migration.Basic and Clinical Pharmacology and Toxicology.(Revised 100年5月) | IL-8 |
| Tsung-Hua Hsieh, Chen-Fung Tsai, Chia-Yi Hsu, Po-Lin Kuo, Jau-Nan Lee, Chee-Yin Chai, Shao-Chun Wang and Eing-Mei Tsai. Phthalates as tumor promoters acting through the AhR/HDAC6/c-Myc signaling pathway in estrogen receptor-negative human breast cancer. Cancer research. (Submitting) | AhR
HDAC6 |
| Chuang-Hao Lin, Rei-Cheng Yang et al.Activation of Trim17 by PPARγ is involved in Di (2-ethylhexyl) phthalate (DEHP)-induced Apoptosis on Neuro-2a cells
(Submitting) | PPARγ |
